Synthesis and intramolecular cyclizationof thiosemicarbazide morpholilacetic acid
نویسندگان
چکیده
منابع مشابه
Synthesis, Structural Studies and Biological Evaluation of Connections of Thiosemicarbazide, 1,2,4-Triazole and 1,3,4-Thiadiazole with Palmitic Acid.
Thirty new derivatives of palmitic acid were efficiently synthesized. All obtained compounds can be divided into three groups of derivatives: Thiosemicarbazides (compounds 1-10), 1,2,4-triazoles (compounds 1a-10a) and 1,3,4-thiadiazoles (compounds 1b-10b) moieties. ¹H-NMR, 13C-NMR and MS methods were used to confirm the structure of derivatives. All obtained compounds were tested in vitro again...
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Thiosemicarbazides are potent intermediates for the synthesis of pharmaceutical and bioactive materials and thus, they are used extensively in the field of medicinal chemistry. The imine bond (-N=CH-) in these compounds are useful in organic synthesis, in particular for the preparation of heterocycles and non-natural β-aminoacids.In this paper the synthesis of some new thiosemicarbazide derivat...
متن کاملSynthesis, spectroscopic, and antimicrobial studies of the bivalent nickel, and copper complexes of thiosemicarbazide.
A series of metal complexes of Ni(II), and Cu(II) having the general composition [M(L)(2)X(2)] with thiosemicarbazide have been prepared and characterized by elemental chemical analysis, molar conductance, magnetic susceptibility measurements, mass, IR, electron paramagnetic resonance, and electronic spectral studies. The IR spectral data suggest the involvement of sulfur and terminal amino nit...
متن کاملSynthesis and Biological Evaluation of Thiosemicarbazide Derivatives Endowed with High Activity toward Mycobacterium Bovis
Thiosemicarbazides are potent intermediates for the synthesis of pharmaceutical and bioactive materials and thus, they are used extensively in the field of medicinal chemistry. The imine bond (-N=CH-) in these compounds are useful in organic synthesis, in particular for the preparation of heterocycles and non-natural β-aminoacids.In this paper the synthesis of some new thiosemicarbazide derivat...
متن کاملLipophilicity Studies on Thiosemicarbazide Derivatives.
The lipophilicity of two series of thiosemicarbazide derivatives was assessed by the RP-HPLC method with the RP-18 chromatographic column and the methanol-water mixture as the mobile phase. Distribution coefficients logPHPLC were compared to calculated values generated by commonly used AClogP software and quantum chemical calculations. The reliability of the predictions was evaluated using the ...
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ژورنال
عنوان ژورنال: Chemical Bulletin of Kazakh National University
سال: 2015
ISSN: 2312-7554
DOI: 10.15328/cb633